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Adverse Reactions. Dosage and How to Take Wellbutrin The initial dose of Wellbutrin SR (bupropion hydrochloride) is 150mg in the morning.. File Format: PDFAdobe Acrobat - View as HTML Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Who should not take Wellbutrin XL Oral?. If you take
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